Covid-19: GPs opt to prioritise all patients with learning disabilities for vaccination
نویسندگان
چکیده
Classic hyperacute rejection is dependent on the activation of terminal components complement. Recently, xenoantibodies with limited abilities to activate classical pathway complement in vitro have been implicated acute vascular xenografts. It unclear how these Abs affect their pathogenic activities vivo. In this study, we demonstrate ability an anti-Gal-α1,3Gal (Gal) IgG1, modest complement-activating vitro, induce xenograft rejection. This was complement, FcγR-mediated interactions, and presence NK cells. Inhibition any one factors resulted abrogation IgG1-mediated contrast, anti-Gal IgG3 mAb induced classic, that solely activation. Our observations implicate two types IgG-mediated rejection; activation, a second uniquely FcγR,
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ژورنال
عنوان ژورنال: BMJ
سال: 2021
ISSN: ['0959-8138']
DOI: https://doi.org/10.1136/bmj.n510